Quasispecies as a matter of fact: Viruses and beyond
نویسندگان
چکیده
منابع مشابه
Viruses as quasispecies: biological implications.
During viral infections, the complex and dynamic distributions of variants, termed viral quasispecies, play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. Mutant spectra are continuously and avoidably generated during RNA genome replication, and they are not just a by-product of error-prone replication, devoid of biological relevanc...
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In their recent review, Más et al. propose that the existence of quasispecies has become a universal rule for RNA viruses and may be extended to other biological systems. Although the historical perspective on quasispecies theory provided by Más et al. serves as a valuable introduction to the subject, their article presents a polarized view of the applicability of quasispecies theory to RNA vir...
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Viral quasispecies are closely related (but nonidentical) mutant and recombinant viral genomes subjected to continuous genetic variation, competition, and selection. Quasispecies structure and dynamics of replicating RNA enable virus populations to persist in their hosts and cause disease. We review mechanisms of viral persistence in cells, organisms, and populations of organisms and suggest th...
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15 صفحه اولQuasispecies Theory and the Behavior of RNA Viruses
A large number of medically important viruses, including HIV, hepatitis C virus, and influenza, have RNA genomes. These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity. This diversity allows a viral population to rapidly adapt to dynamic environments and evolve resistance to vaccines and antiviral drugs. For the last 30 years, quasispecies theory h...
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ژورنال
عنوان ژورنال: Virus Research
سال: 2011
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2011.09.018